Bioequivalence of a Dosage form of the New Drug Mefebut

Bioequivalence of a Dosage form of the New Drug Mefebut

The bioequivalence of mefebut drug substance and its tablet dosage form was investigated by studying the main pharmacokinetic parameters and calculating the relative bioavailability. The results showed that mefebut circulated for up to 4 h in rabbit blood after peroral administration. The relative b...

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Veröffentlicht in:Pharmaceutical chemistry journal 2018-09, Vol.52 (6), p.495-496
Hauptverfasser: Smirnova, L. A., Suchkov, E. A., Ryabukha, A. F., Kuznetsov, K. A., Velikopol’skaya, M. V., Tyurenkov, I. N., Bakulin, D. A., Stepanova, É. F., Shevchenko, A. M.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:The bioequivalence of mefebut drug substance and its tablet dosage form was investigated by studying the main pharmacokinetic parameters and calculating the relative bioavailability. The results showed that mefebut circulated for up to 4 h in rabbit blood after peroral administration. The relative bioavailability was 97.4%.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1846-x