Immobilization of Benzocaine in Polymeric Nanocontainers. Pharmacokinetic Modeling

The possibility of immobilizing benzocaine in polymeric nanocontainers made of sulfonated cation exchangers, i.e., sulfonated polycalixarene and KU-23 30/100, was studied. The desorption kinetics of neutral and cationic benzocaine from the polymeric nanocontainers provided the desired drug-release p...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2018-08, Vol.52 (5), p.464-466
Hauptverfasser:	Shkurenko, G. Yu, Lyrshchikov, S. Yu, Gorlov, A. A., Al’tshuler, O. G., Al’tshuler, G. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Synthesis Methods and Manufacturing Technology Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy
Online-Zugang:	Volltext
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Zusammenfassung:	The possibility of immobilizing benzocaine in polymeric nanocontainers made of sulfonated cation exchangers, i.e., sulfonated polycalixarene and KU-23 30/100, was studied. The desorption kinetics of neutral and cationic benzocaine from the polymeric nanocontainers provided the desired drug-release pharmacokinetics upon peroral administration.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-018-1840-3