Cyclodextrin Based Nanosponge as a Biodegradable Porous Three-Dimensional Nanocatalyst in the One-Pot Synthesis of N- Containing Organic Scaffolds

The motivation behind the present study was to develop an application of [beta]-cyclodextrin-based nanosponges with the tiny mesh-like structure as porous three-dimensional nanocatalyst in the one-pot three component condensations of various aromatic aldehydes with activated methylene compounds such as dimedone, thiobarbituric acid, 4-hydroxycoumarin, 4-hydroxy-6-methyl-2-pyrone and nucleophiles including indole and amines. This nanosponge catalyst afforded the privileged N- containing organic scaffolds as key intermediates in pharmaceutical chemistry in very short reaction times.