Synthesis and Pharmacological Activity of Some [alpha]-Aminoketone Hydrochlorides

Synthesis and Pharmacological Activity of Some [alpha]-Aminoketone Hydrochlorides

New [alpha]-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et.sub.2O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was...

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Veröffentlicht in:Pharmaceutical chemistry journal 2017-05, Vol.51 (2), p.107
Hauptverfasser: Gevorgyan, G. A, Gasparyan, N. K, Papoyan, O. A, Avakimyan, D. A, Tatevosyan, A. A, Panosyan, H. A
Format: Artikel
Sprache:eng
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Zusammenfassung:New [alpha]-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et.sub.2O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.
ISSN:0091-150X
DOI:10.1007/s11094-017-1565-8