QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-[beta]-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM

QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-[beta]-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM

In this paper, a sensitive, rapid, and simple flow-injection chemiluminescence (FI-CL) technique is described for determining cefradine in human urine and capsule samples at the picogram level. The results show that cefradine within 0.1-100.0 nmol/L quantitatively quenches the CL intensity of the lu...

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Veröffentlicht in:Journal of applied spectroscopy 2018-05, Vol.85 (2), p.327
Hauptverfasser: Shen, M.X, Tan, X.J, Song, Zh. H
Format: Artikel
Sprache:eng
Schlagworte:
Cyclodextrins
Luminol
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Zusammenfassung:In this paper, a sensitive, rapid, and simple flow-injection chemiluminescence (FI-CL) technique is described for determining cefradine in human urine and capsule samples at the picogram level. The results show that cefradine within 0.1-100.0 nmol/L quantitatively quenches the CL intensity of the luminol/sulfobutylether-[beta]- cyclodextrin (SBE-[beta]-CD) system, with a relative correlation coefficient r of 0.9931. Subsequently, the possible mechanism for the quenching phenomenon is discussed in detail using the FI-CL and molecular docking methods. The proposed CL method, with a detection limit of 0.03 nmol/L (3a) and relative standard deviations
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-018-0652-2