Can the Intermittent Training Generate Alterations on the Liver Tissue of Rats Submitted to a Hyperlipidic Diet?/El Entrenamiento Intermitente Puede Generar Alteraciones sobre el Tejido Hepatico de Ratas Sometidas a una Dieta Alta en Grasa?

Studies indicate that increasing physical activity and decreasing levels of fat in the liver help to decrease the risk of morbidity from liver conditions. This study aimed to evaluate the effects of an eight week intermittent training program on the liver tissue of rats subjected to a hyperlipidic diet. The study consisted of 30 male Wistar rats, divided into the following groups: Sedentary Control (SC) Exercise Control (EC) (fed on standard feed and water) Sedentary Obese (SO) and Exercise Obese (EO) (fed on bacon, ham, sausage, biscuits, soda and standard feed), which performed intermittent training through electrically stimulated jumps, with three sets of 12 repetitions, three times per week for eight weeks. At the end of the training period, the animals were euthanized, and their livers removed for histological processing and hematoxylin and eosin staining (HE). Soon afterwards, caryometric analysis of the hepatocyte nuclei was performed. From the presented results it can be seen that the hepatocyte nuclei of the obese animals were smaller in relation to those of the control animals, therefore, exercise combined with an appropriate diet proved to be efficient in not causing alterations in the hepatocyte nuclei, conserving normal cell function and reducing the chances of the appearance of tissue damage. Furthermore, exercise in isolation cannot be considered a protective factor against the alteration of the liver cells. KEY WORDS: High fat diet; Exercise; Hepatocytes. Estudios indican que el aumento de la actividad fisica y la disminucion de los niveles de grasa en el higado ayudan a reducir el riesgo de morbilidad por enfermedades hepaticas. El objetivo fue evaluar el efecto de un programa de entrenamiento intermitente de ocho semanas en el tejido hepatico de ratas con dieta alta en grasa. Treinta ratas Wistar machos fueron divididas en grupos Control Sedentario (SC), Control Ejercicio (CE) (con fuente de alimentacion que consiste en la racion estandar y agua), Obeso Sedentario (OS) y Obeso Ejercicio (OE) (con alimentacion compuesta por tocino, mortadela, salchichas, galletas, refrescos y racion estandar), sometidas a un entrenamiento intermitente a traves de saltos mediante estimulacion electrica con tres series de 12 repeticiones, tres veces por semana durante ocho semanas. Al final del periodo de entrenamiento, los animales fueron sacrificados; se extrajeron sus higados para el procesamiento histologico y tincion con hematoxilina y eosina (HE). Lueg