Synthesis and Bioactivity of N-Myrtenamides Containing a Heterocycle

A series of N-(4-(N'-substituted sulfamoyl)phenyl)myrtenamides containing a heterocycle were designed and synthesized by a multiple-step procedure using [alpha]-pinene as starting material. All the synthesized compounds were characterized and analyzed by GC, HPLC, UV-vis, FTIR, NMR, GC-MS, and ESI-MS. The preliminary bioassay showed that, at 50 [mu]g/mL, the target compounds exhibited a certain antifungal activity against the five tested fungi, in which compound 5f exhibited antifungal activity of 83.2% and 70.0% against Physalospora piricola and Alternaria solani, respectively. Moreover, compound 5d displayed herbicidal activity of 86.0% against the root of rape (Brassica campestris) at 100 [mu]g/mL.