Preparation and biological profile of .sup.99mTc-lidocaine as a cardioselective imaging agent using .sup.99mTc eluted from .sup.99Mo/.sup.99mTc generator based on Al-Mo gel

The current study is aimed to prepare .sup.99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used .sup.99mTc was obtained from Al-.sup.99Mo-molybdate(VI) gel matrix. .sup.99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied .sup.99mTc-valsartan and .sup.99mTc-procainamide. Consequently, .sup.99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of .sup.99mTc-lidocaine for sodium channels in the heart.