Synthesis of 2-Aryl-4,5-BisImidazoles from Polyfluoroalkanethiocarboxylic Acid Amides

Synthesis of 2-Aryl-4,5-BisImidazoles from Polyfluoroalkanethiocarboxylic Acid Amides

Polyfluoroalkanethiocarboxylic acid amides react with aromatic aldehydes with the formation of bis(N-thioacyl)aminals. Treating the latter with acyl chlorides gives 2-aryl-substituted 4,5-bis(polyfluoroalkyl)imidazoles which constitutes a novel method of synthesizing these imidazole derivatives.

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2015-02, Vol.51 (2), p.128
Hauptverfasser: Mykhaylychenko, Sergey S, Pikun, Nadezhda V, Rusanov, Eduard B, Shermolovich, Yuriy G
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Amides
Chemical properties
Fluorides
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Zusammenfassung:Polyfluoroalkanethiocarboxylic acid amides react with aromatic aldehydes with the formation of bis(N-thioacyl)aminals. Treating the latter with acyl chlorides gives 2-aryl-substituted 4,5-bis(polyfluoroalkyl)imidazoles which constitutes a novel method of synthesizing these imidazole derivatives.
ISSN:0009-3122
DOI:10.1007/s10593-015-1669-6