Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles
New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.
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| Veröffentlicht in: | Chemistry of natural compounds 2014-12, Vol.50 (6), p.1016-1023 |
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| container_issue | 6 |
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| container_title | Chemistry of natural compounds |
| container_volume | 50 |
| creator | Antimonova, A. N Petrenko, N. I Shakirov, M. M Pokrovskii, M. A Pokrovskii, A. G Shul’ts, E. E |
| description | New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models. |
| doi_str_mv | 10.1007/s10600-014-1150-2 |
| format | Article |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | chemistry cytotoxicity humans Hydrolysis lupane Medicine neoplasm cells Organic Chemistry Pharmacy Plant Sciences |
| title | Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles |
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