Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles

Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles

New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.

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Veröffentlicht in:Chemistry of natural compounds 2014-12, Vol.50 (6), p.1016-1023
Hauptverfasser: Antimonova, A. N, Petrenko, N. I, Shakirov, M. M, Pokrovskii, M. A, Pokrovskii, A. G, Shul’ts, E. E
Format: Artikel
Sprache:eng
Schlagworte:
chemistry
cytotoxicity
humans
Hydrolysis
lupane
Medicine
neoplasm cells
Organic Chemistry
Pharmacy
Plant Sciences
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Zusammenfassung:New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-014-1150-2