Synthesis and Biological Activity of New 1,3-Benzothiazole Derivatives

Synthesis and Biological Activity of New 1,3-Benzothiazole Derivatives

2-Benzothiazolylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic and 4-aryl-3-bromo-2,4-dioxobutanoic acids in addition to complexes with manganese, cobalt, and copper were synthesized. Their hypoglycemic and antimicrobial activity was studied. Compounds with low toxicity and activity comparable to or ex...

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Veröffentlicht in:Pharmaceutical chemistry journal 2014-11, Vol.48 (8), p.505-508
Hauptverfasser: Pulina, N. A., Sobin, F. V., Yushkova, T. A., Odegova, T. F., Krasnova, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Cobalt
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:2-Benzothiazolylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic and 4-aryl-3-bromo-2,4-dioxobutanoic acids in addition to complexes with manganese, cobalt, and copper were synthesized. Their hypoglycemic and antimicrobial activity was studied. Compounds with low toxicity and activity comparable to or exceeding that of reference drugs were discovered.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1139-y