Biochemical and Morphological Changes in White Rats After Intragastric Injecton of a Synthetic Nanobiocomposite Based on Silver Nanoparticles and Arabinogalactan

Results from the synthesis and biological testing of a new nanobiocomposite containing silver (Ag) nanoparticles encapsulated in the natural biologically active polymer arabinogalactan were presented. The physicochemical properties of the water-soluble Ag-containing polymeric nanocomposite were desc...

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Veröffentlicht in:Pharmaceutical chemistry journal 2014-09, Vol.48 (6), p.387-390
Hauptverfasser: Novikov, M. A., Titov, E. A., Sosedova, L. M., Ostroukhova, L. A., Trofimova, N. N., Babkin, V. A.
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Sprache:eng
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Zusammenfassung:Results from the synthesis and biological testing of a new nanobiocomposite containing silver (Ag) nanoparticles encapsulated in the natural biologically active polymer arabinogalactan were presented. The physicochemical properties of the water-soluble Ag-containing polymeric nanocomposite were described. It was found that the new nanocomposite upon intragastric injection to white rats activated the antioxidant system, caused slight changes in brain and liver tissues, and produced biochemical shifts characteristic of compensatory—adaptive stress mechanisms.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1116-5