1,2,3-Thiadiazolyl isocyanates in the synthesis of biologically active compounds. Study of the cytotoxic activity of N-urea

A simple method is proposed for the synthesis of 1, 2, 3-thiadiazolylureas by the reaction of 1, 2, 3-thiadiazolyl isocyanates with primary amines. 1, 2, 3-Thiadiazolyl isocyanates were obtained in situ by the Curtius rearrangement of 1, 2, 3-thiadiazolylcarbonyl azides. Cytokinin activity was tested for N-(4-methyl-1, 2, 3-thiadiazol-5-yl)-N'-(4-methylphenyl)urea, which is an analog of thidiazuron, differing in the presence of two methyl groups in the molecule. Keywords: 6-benzylaminopurine, cytokinin, isocyanates, 1, 2, 3-thiadiazole, thidiazuron, ureas.