Synthesis of 5-Trifluoroacetylpyrrole-2-Carbaldehydes

Synthesis of 5-Trifluoroacetylpyrrole-2-Carbaldehydes

5-Trifluoroacetylpyrrole-2-carbaldehydes were synthesized by low-temperature trifluoroacetylation of pyrrole-2-carbaldehyde acetals using trifluoroacetic anhydride, with subsequent removal of the acetal protecting group by mild acid-catalysed hydrolysis. The hydrolysis was accompanied by the formati...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-10, Vol.50 (7), p.941-945
Hauptverfasser: Petrova, O. V., Markova, M. V., Ushakov, I. A., Sobenina, L. N., Tretyakov, E. V., Ovcharenko, V. I., Mikhaleva, A. I., Trofimov, B. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Heterocyclic compounds
Hydrolysis
Organic Chemistry
Pharmacy
Thiophene
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Zusammenfassung:5-Trifluoroacetylpyrrole-2-carbaldehydes were synthesized by low-temperature trifluoroacetylation of pyrrole-2-carbaldehyde acetals using trifluoroacetic anhydride, with subsequent removal of the acetal protecting group by mild acid-catalysed hydrolysis. The hydrolysis was accompanied by the formation of a minor product, (1Е,4Е)-1,5-bis[5-(2,2,2-trifluoroacetyl)-1Н-pyrrol-2-yl]-1,4-pentadien-3-one, which was isolated and identified.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1548-6