An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides

We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaroma...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-04, Vol.50 (1), p.19-25
Hauptverfasser: Bumagin, N. A., Veselov, I. S., Belov, D. S.
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container_title Chemistry of heterocyclic compounds (New York, N.Y. 1965)
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creator Bumagin, N. A.
Veselov, I. S.
Belov, D. S.
description We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaromatic biaryls with furyl and thienyl groups.
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subjects Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Halides
Organic Chemistry
Palladium
Pharmacy
Substitution reactions
title An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides
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