An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides

An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides

We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaroma...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-04, Vol.50 (1), p.19-25
Hauptverfasser: Bumagin, N. A., Veselov, I. S., Belov, D. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Halides
Organic Chemistry
Palladium
Pharmacy
Substitution reactions
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Zusammenfassung:We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaromatic biaryls with furyl and thienyl groups.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1443-1