Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Background:Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their associa...

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Veröffentlicht in:PLoS ONE 2014, Vol.9 (4)
Hauptverfasser: Sanoff, Hanna K, Renfro, Lindsay A, Poonnen, Pradeep, Ambadwar, Pratibha, Sargent, Daniel J, Goldberg, Richard M, McLeod, Howard
Format: Report
Sprache:eng
Schlagworte:
Care and treatment
Colorectal cancer
Development and progression
Genetic aspects
Genetic polymorphisms
Genetic susceptibility
Health aspects
Metastasis
Physiological aspects
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Zusammenfassung:Background:Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0094727