Novel structural analogs of glyphosate based on azoles. 1. Synthesis of 1H-imidazoles containing carboxyl and phosphoryl groups in the ring

Novel structural analogs of glyphosate based on azoles. 1. Synthesis of 1H-imidazoles containing carboxyl and phosphoryl groups in the ring

A general method has been developed for the synthesis of 1H-imidazoles containing a phosphoryl group in positions 2 or 4(5) based on lithium intermediates. The possibility of further functionalization of the ring using electrophiles has also been demonstrated.

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2011-04, Vol.47 (1), p.36-44
Hauptverfasser: Pavlenko, N. V., Oos, T. I., Yagupolskii, Yu. L., van Almsick, A., Willms, L.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Glyphosate
Hydrolysis
Organic Chemistry
Pharmacy
Phosphonates
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Beschreibung
Zusammenfassung:A general method has been developed for the synthesis of 1H-imidazoles containing a phosphoryl group in positions 2 or 4(5) based on lithium intermediates. The possibility of further functionalization of the ring using electrophiles has also been demonstrated.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-011-0717-0