Technetium(I) tricarbonyl complexed with the N-heterocyclic aldehyde thiosemicarbazones: potential precursors of the radiopharmaceuticals

Technetium(I) tricarbonyl complexes may form with the pyridine aldehyde thiosemicarbazones (TSCs), in which chelating ligand is bound tri- or bidentately. Intend of the presented work was to check, if labeling the N -heterocyclic TSCs with tricarbonyl [ 99m Tc]-technetium(I) may lead to formation of the complexes suitable for the radiopharmaceutical purposes. Syntheses of the complexes were provided in the conditions analogous to those performed in the nuclear medicine laboratories. Main physicochemical properties of the complexes important in the medicinal chemistry were studied. Relevant results of the numerical calculations remain in fair agreement with these properties.