Synthesis and antitumor activity of 2-N- and 3-S-substituted 5-[2-(4-)benzyloxyphenyl]-1,2,4-triazoles and acylhydrazides

3-Thio-4-phenyl-5-[2-(4-)benzyloxyphenyl]-1,2,4-triazoles were prepared by cyclization of the corresponding thiosemicarbazides in alkaline medium. The 2- N -substituted derivatives of the aforementioned triazoles were obtained via aminomethylation, cyanethylation, and alkylation of α-epoxides. 3- S -Substituted 1,2,4-triazoles were synthesized by alkylation with various aliphatic and aromatic halides. Acylhydrazides were prepared via reaction of 2-(4-)benzyloxybenzoic acid hydrazides with dicarboxylic acid anhydrides. The antitumor activity of the synthesized compounds was studied.