Complex filler for direct molding based on lactose and microcrystalline cellulose

The effects of lactose and microcrystalline cellulose on the flowability and moldability of a tabletting mixture and the quality of tablets obtained by direct pressing have been investigated. The optimum composition of a complex filler for direct pressing of tablets is proposed. The possibility of r...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2010-08, Vol.44 (4), p.216-218
Hauptverfasser:	Zhuikova, N. N, Sablina, O. S, Shtokareva, E. A, Gavrilov, A. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellulose complex filler direct pressing Lactose Medicine microcrystalline cellulose Organic Chemistry Pharmacology/Toxicology Pharmacy
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Beschreibung
Zusammenfassung:	The effects of lactose and microcrystalline cellulose on the flowability and moldability of a tabletting mixture and the quality of tablets obtained by direct pressing have been investigated. The optimum composition of a complex filler for direct pressing of tablets is proposed. The possibility of replacing the technology of wet granulation by direct pressing for five well-known medicinal preparations is established.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-010-0435-4