New palladium(II) complexes with pyrazole ligands: Part II. Synthesis, spectral and thermal studies, and antitumor evaluation

This study describes the synthesis, IR, 1 H, and 13 C{ 1 H} NMR spectroscopic as well the thermal characterization of the new palladium(II) pyrazolyl complexes [PdCl 2 (HmPz) 2 ] 1 , [PdBr 2 (HmPz) 2 ] 2 , [PdI 2 (HmPz) 2 ] 3 , [Pd(SCN) 2 (HmPz) 2 ] 4 {HmPz = 4-methylpyrazole}. The residues of the thermal decomposition were identified as Pd 0 by X-ray powder diffraction. From the initial decomposition temperatures, the thermal stability of the complexes can be ordered in the sequence: 1 > 2 > 4 ≈ 3 . The cytotoxic activities of the complexes and the ligand were investigated against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07) and compared to cisplatin under the same experimental conditions.