Synthesis and calming activity of 2-amino-4--substituted phenylpyrimidines

Using helicid as starting material, E-4-[beta]-D-allopyranoside-cinnamic-4- substituted phenylketones (1a-1h) containing the structure of chalcones were synthesized; then these chalcones were reacted with guanidine hydrochloride through a 1,4-Michael reaction, giving 2-amino-4-(4-[beta]-D- allopyranoside-phenyl)-6-3(4)-substituted phenylpyrimidines (2a-2h), which were characterized by IR, [sup.1]H NMR, and HR-MS. The target compounds were evaluated by the spontaneous locomotor activity test, showing that all of them had good calming activity; compound 2f was found to have the greatest.