Investigation of the chlorination of 4--diones

Investigation of the chlorination of 4--diones

Chlorination of 4-(perfluoroalkyl)-5-(p-toluenesulfonyl)-2,6- bis(trimethylsilyloxy)pyrimidines led to the formation of 5-chloro-6-(perfluoroalkyl)-5-(p-toluenesulfonyl)pyrimidine- 2,4(3H,5H)-diones, the structure of which was confirmed by NMR spectroscopy and X-ray structural analysis. The reaction...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-07, Vol.49 (4), p.591
Hauptverfasser: Gudz, A.P, Kanishchev, A.S, Vlasenko, Yu. G, Chernega, A.N, Shermolovich, Yu. G
Format: Artikel
Sprache:eng
Schlagworte:
Nuclear magnetic resonance spectroscopy
Nucleosides
Nucleotides
Physiological aspects
Pyrimidines
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Zusammenfassung:Chlorination of 4-(perfluoroalkyl)-5-(p-toluenesulfonyl)-2,6- bis(trimethylsilyloxy)pyrimidines led to the formation of 5-chloro-6-(perfluoroalkyl)-5-(p-toluenesulfonyl)pyrimidine- 2,4(3H,5H)-diones, the structure of which was confirmed by NMR spectroscopy and X-ray structural analysis. The reactions of chlorinatedpyrimidine-2,4(3H,5H)-diones with nucleophiles were investigated. Keywords: chlorohydrin, pyrimidinone, uracil, chlorination, silylation.
ISSN:0009-3122