Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers

Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers

Copolymers of N -vinylpyrrolidone and 2-methyl-5-vinyltetrazole with various ratios of monomer units were synthesized by radical polymerization using the injection method. The copolymerization parameters for these monomers were calculated by the Kelen―Tudos method (r 1 = 14.34; r 2 = 0.06) for high...

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Veröffentlicht in:Pharmaceutical chemistry journal 2013-03, Vol.46 (12), p.726-729
Hauptverfasser: Kedik, S. A., Sakaeva, I. V., Kochkina (Cherta), Yu. V., Eremin, D. V., Panov, A. V., Suslov, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polymerization
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Zusammenfassung:Copolymers of N -vinylpyrrolidone and 2-methyl-5-vinyltetrazole with various ratios of monomer units were synthesized by radical polymerization using the injection method. The copolymerization parameters for these monomers were calculated by the Kelen―Tudos method (r 1 = 14.34; r 2 = 0.06) for high degrees of conversion. Copolymers with monomer-unit concentrations up to 70 ± 5 mol% were soluble in water, non-toxic, and effective as radioprotectors.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0879-4