Role for protein-protein interaction databases in human genetics

Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible...

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Veröffentlicht in:Expert review of pharmacoeconomics & outcomes research 2009-12, Vol.6 (6), p.647-659
Hauptverfasser: Pattin, Kristine A, Moore, Jason H
Format: Artikel
Sprache:eng
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Zusammenfassung:Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly available to the scientific community. As our knowledge of protein-protein interactions increases, it is important to give thought to the different ways that these resources can impact biomedical research. In this article, we highlight the importance of protein-protein interactions in human genetics and genetic epidemiology. Since protein-protein interactions demonstrate one of the strongest functional relationships between genes, combining genomic data with available proteomic data may provide us with a more in-depth understanding of common human diseases. In this review, we will discuss some of the fundamentals of protein interactions, the databases that are publicly available and how information from these databases can be used to facilitate genome-wide genetic studies.
ISSN:1473-7167
1478-9450
1744-8387
DOI:10.1586/epr.09.86