Nanoscale architecture of integrin-based cell adhesions

Nanoscale architecture of integrin-based cell adhesions

Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing (1,2). Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling (1-3). Focal adhesions consist of a complex ne...

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Veröffentlicht in:Nature 2010, Vol.468 (7323), p.580
Hauptverfasser: Kanchanawong, Pakorn, Shtengel, Gleb, Pasapera, Ana M, Ramko, Ericka B, Davidson, Michael W, Hess, Harald F, Waterman, Clare M
Format: Report
Sprache:eng
Schlagworte:
Cell adhesion
Integrins
Nanotechnology
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Zusammenfassung:Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing (1,2). Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling (1-3). Focal adhesions consist of a complex network (4) of trans-plasma-membrane integrins and cytoplasmic proteins that form a
ISSN:0028-0836
DOI:10.1038/nature09621