A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbe...

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Veröffentlicht in:Nature neuroscience 2004-06, Vol.7 (6), p.585-586
Hauptverfasser: Castillo, Pablo E, Manzoni, Olivier J, Mato, Susana, Chevaleyre, Vivien, Robbe, David, Pazos, Angel
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Neuroplasticity
Physiological aspects
Tetrahydrocannabinol
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Zusammenfassung:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.
ISSN:1097-6256
1546-1726
DOI:10.1038/nn1251