High-Fiber Cereal Reduces Postprandial Insulin Responses in Hyperinsulinemic but not Normoinsulinemic Subjects

High-Fiber Cereal Reduces Postprandial Insulin Responses in Hyperinsulinemic but not Normoinsulinemic Subjects Thomas M.S. Wolever , DM, PHD 1 2 , Janice E. Campbell , MSC 1 , Daniela Geleva , PHD 3 and G. Harvey Anderson , PHD 1 1 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 2 Division of Endocrinology and Metabolism, St. Michael’s Hospital, Toronto, Ontario, Canada 3 General Mills, Minneapolis, Minnesota Address correspondence and reprint requests to Thomas MS Wolever, DM, PhD, Department of Nutritional Sciences, 150 College St., Room 316, Toronto, Ontario, Canada M5S 3E2. E-mail: thomas.wolever{at}utoronto.ca Abstract OBJECTIVE —The objective of this study was to compare the plasma glucose and insulin responses elicited by two ready-to-eat breakfast cereals (one being high and the other being low in cereal fiber) and to see if the differences in response depended on subjects’ fasting plasma insulin. RESEARCH DESIGN AND METHODS —Nondiabetic men ( n = 77) were studied on two occasions after 10- to 14-h overnight fasts. They consumed 25 g of available carbohydrate from high- or low-fiber breakfast cereals in random order with blood taken at intervals for 2 h. Data from the 42 men with high fasting plasma insulin (FPI) on screening (>40 pmol/l) were compared with those from the 35 men with normal FPI (≤40 pmol/l). RESULTS —Hyperinsulinemic men had significantly higher waist circumference and BMI, lower HDL cholesterol, and a trend toward higher triglycerides ( P = 0.07) than control subjects. In all 77 subjects, the incremental area under the glucose response curve (AUC) after high-fiber cereal was 11.8 ± 5.5% ( P = 0.036) less than after low-fiber cereal with the reductions being equivalent in the hyperinsulinemic (12.6 ± 8.3%) and control (10.9 ± 9.1%) groups. However, insulin peak rise was reduced by the high-fiber cereal only in hyperinsulinemic men (351 ± 29 vs. 485 ± 55 pmol/l) but not in control subjects (211 ± 20 vs. 220 ± 20 pmol/l; cereal × group interaction P = 0.044). Insulin AUC after the high-fiber cereal, expressed as a percentage of that after low-fiber cereal, was negatively related to FPI ( P = 0.009) but not to age, BMI, or waist circumference. CONCLUSIONS —The high-fiber cereal reduced glucose responses to the same extent in normal and hyperinsulinemic men, but reduced insulin responses only in hyperinsulinemic subjects. AUC, area under the curve FPI, fasting plasma insulin GIP,