"Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era

Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit th...

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Veröffentlicht in:Annual review of psychology 2021-01, Vol.72 (1), p.37-60
1. Verfasser: Harden, K. Paige
Format: Artikel
Sprache:eng
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Zusammenfassung:Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.
ISSN:0066-4308
1545-2085
1545-2085
DOI:10.1146/annurev-psych-052220-103822