Nosocomial transmission of NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center associated with patients from Ukraine

We studied nosocomial transmission of multidrug-resistant bla.sub.NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center. Whole-genome multilocus sequence typing revealed two genetic clusters consisting of 2 and 5 K. pneumoniae isolates, both from Ukrainian medical evacuee...

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Veröffentlicht in:	BMC Infectious Diseases 2024, Vol.24 (1)
Hauptverfasser:	Smit, Wouter L, Wunderink, Herman F, Kluytmans, Jan A. J. W, Tissing, Wim J. E, van Dijkhuizen, E. H. Pieter, Loeffen, Yvette G. T, Hendrickx, Antoni P. A, Notermans, D. W, van Arkel, A. L. E, Hall, M. A. Leversteijn-van, van den Bijllaardt, W, van Mansfeld, R, van Dijk, K, Zwart, B, Diederen, B. M. W, Berkhout, H, Ott, A, Waar, K, Ang, W, da Silva, J, Vlek, A. L. M, Buiting, A. G. M, Bode, L. G. M, Jansz, A, Paltansing, S, van Griethuysen, A. J, Foe, J. R. Lo Ten, van Trijp, M. J. C. A, Wong, M, Muller, A. E, van der Linden, M. P. M, van Rijn, M, Debast, S. B, Kolwijck, E, Al Naiemi, N, Schulin, T, Dinant, S, van Mens, S. P, Melles, D. C, Stuart, J. W. T. Cohen, Gruteke, P, van Dam, A, Maat, I, Maraha, B, Sinnige, J. C, van der Vorm, E, van Meer, M. P. A, de Graaf, M, de Jong, E, Vainio, S. J, Heikens, E, Reijer, M.den, Dorigo-Zetsma, J. W, Troelstra, A, Bathoorn, E, de Vries, J, van Dam, D. W, de Brauwer, E. I. G. B, Steingrover, R
Format:	Report
Sprache:	eng
Schlagworte:	Cancer patients Causes of Cross infection Disease transmission Diseases Klebsiella infections Medical centers Nosocomial infections Pediatric research
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Beschreibung
Zusammenfassung:	We studied nosocomial transmission of multidrug-resistant bla.sub.NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center. Whole-genome multilocus sequence typing revealed two genetic clusters consisting of 2 and 5 K. pneumoniae isolates, both from Ukrainian medical evacuees and Dutch patients. Ukrainian patients were colonized at admission, and two Dutch patients developed bacteremia. Temporal and spatial transmission links were assessed and sampling of sinks revealed environmental contamination of bla.sub.NDM-1-containing K. pneumoniae with genetic relatedness to cluster isolates. Phylogenetic analysis of 163 K. pneumoniae ST147 isolates from the Dutch national surveillance revealed that transmission-related isolates formed a unique phylogenetic branch.
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-024-10368-2