Vitamin D deficiency and the vitamin D receptor

Vitamin D deficiency and the vitamin D receptor

Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis usi...

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Veröffentlicht in:PloS one 2024-03, Vol.19 (3), p.e0297138
Hauptverfasser: Nabil, Imrul Kayes, Mahmud, Zimam, Tamanna, Sonia, Rahman, Md Mostafijur, Rashid, Gowhar, Hossain, Md. Sarowar, Asad, Humaira Binte, Kamal, Mohammad Amjad, Howlader, Md. Zakir Hossain
Format: Artikel
Sprache:eng
Schlagworte:
Alfacalcidol
Analysis
Calcifediol
Care and treatment
Comparative analysis
Diagnosis
Diet therapy
Genes
Genetic polymorphisms
Health aspects
Hypertension
Medical research
Medicine, Experimental
Risk factors
Vitamin D
Vitamin D deficiency
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Zusammenfassung:Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis using HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed in hypertensive individuals compared to controls (p0.05). Similarly, no significant difference was found in the VDR gene BsmI genotype frequency between hypertensive patients and controls (p>0.05). However, a statistically significant distinction was observed in the VDR gene FokI genotype frequency between cases and controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0297138