Effect of switching from nucleos

Effect of switching from nucleos

Induction of a durable viral response is difficult to achieve in patients with chronic hepatitis B (CHB), even from long-term use of a nucleos(t)ide analogue (NA). This study investigated whether switching to peginterferon (PegIFN) alfa-2a after long-term NA therapy induced a durable viral response....

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Veröffentlicht in:PloS one 2022-07, Vol.17 (7), p.e0270716
Hauptverfasser: Woo, Hyun Young, Heo, Jeong, Tak, Won Young, Lee, Heon Ju, Chung, Woo Jin, Park, Jung Gil, Park, Soo Young, Park, Young Joo, Lee, Yu Rim, Hwang, Jae Seok, Kweon, Young Oh
Format: Artikel
Sprache:eng
Schlagworte:
Comparative analysis
Drug therapy
Hepatitis B
Nucleoside analogs
Peginterferon alfa-2a
Testing
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Zusammenfassung:Induction of a durable viral response is difficult to achieve in patients with chronic hepatitis B (CHB), even from long-term use of a nucleos(t)ide analogue (NA). This study investigated whether switching to peginterferon (PegIFN) alfa-2a after long-term NA therapy induced a durable viral response. We randomized 149 CHB patients to the two groups. Compared to baseline, the HBsAg levels in both groups were not lower at week 12, but were lower after 24, 36, and 48 weeks (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0270716