Development of recombinant human granulocyte colony-stimulating factor

The granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that has important clinical applications for treating neutropenia. Nartograstim is a recombinant variant of human G-CSF. Nartograstim has been produced in Escherichia coli as inclusion bodies (IB) and presents higher stabi...

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Veröffentlicht in:	Applied microbiology and biotechnology 2021-01, Vol.105 (1), p.169
Hauptverfasser:	Eguia, Fara A. P, Mascarelli, Daniele E, Carvalho, Eneas, Rodríguez, Gretel R, Makiyama, Edson, Borelli, Primavera, Lieberman, Celia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Biotechnology industry Chemical properties Control Culture media (Biology) Escherichia coli Granulocyte colony-stimulating factor Production management Production processes
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