Comparative efficacy of tenofovir and entecavir in nucleos

Comparative efficacy of tenofovir and entecavir in nucleos

To compare the efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B. The Web of Science, PubMed, Cochrane Library, EMBASE, Clinical Trials and China National Knowledge Infrastructure(CNKI) databases were electronically searched to collect randomized controlled tria...

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Veröffentlicht in:PloS one 2019-11, Vol.14 (11), p.e0224773
Hauptverfasser: Chen, Mao-bing, Wang, Hua, Zheng, Qi-han, Zheng, Xu-wen, Fan, Jin-nuo, Ding, Yun-long, Niu, Jia-li, Kim, Seung Up
Format: Artikel
Sprache:eng
Schlagworte:
Antiretroviral agents
Carcinoma
Comparative analysis
Creatine
Creatine kinase
Entecavir
Hepatitis B
Hepatitis B virus
Hepatocellular carcinoma
Tenofovir
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Zusammenfassung:To compare the efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B. The Web of Science, PubMed, Cochrane Library, EMBASE, Clinical Trials and China National Knowledge Infrastructure(CNKI) databases were electronically searched to collect randomized controlled trials (RCTs) regarding the comparison between tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B (CHB) since the date of database inception to July 2019. Two researchers independently screened and evaluated the obtained studies and extracted the outcome indexes. RevMan 5.3 software was used for the meta-analysis. Early on, tenofovir had a greater ability to inhibit the hepatitis B virus, I.sup.2 = 0% [RR = 1.08, 95% CI (1.03, 1.13), P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0224773