Clinical epidemiology and mortality on patients with acute respiratory distress syndrome

The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age [greate...

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Veröffentlicht in:PloS one 2019-08, Vol.14 (8), p.e0221114
Hauptverfasser: Chinh, Luong Quoc, Manabe, Toshie, Son, Do Ngoc, Chi, Nguyen Van, Fujikura, Yuji, Binh, Nguyen Gia, Co, Dao Xuan, Tuan, Dang Quoc, Ton, Mai Duy, Dai, Khuong Quoc, Thach, Pham The, Nagase, Hiroyuki, Kudo, Koichiro, Nguyen, Dat Anh
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Sprache:eng
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Zusammenfassung:The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age [greater than or equal to]18 years) who were admitted and diagnosed with ARDS during 2015-2017. Data on patients' general and clinical conditions, radiographic findings, ventilator settings, gas exchange, and treatment methods were collected and compared between survivors and non-survivors. Risk factors for mortality were assessed using logistic regression analysis. Among 126 eligible patients with ARDS admitted to the central tertiary hospital in Vietnam, we observed high mortality (57.1%). Of the total patients, 91.3% were transferred from local hospitals with a diagnosis of severe pneumonia and then diagnosed with ARDS at the central hospital. At the time of admission, 53.2% of patients had severe ARDS, 37.3% had moderate ARDS, and 9.5% had mild ARDS. The mean (standard deviation) sequential organ failure assessment (SOFA) score was 9.5 (3.4) in non-survivors and 7.4 (3.4) in survivors (p = 0.002). Although there was no significant difference in PaO.sub.2 /FiO.sub.2 on admission between non-survivors and survivors, that on day 3 after admission was significantly different (p = 0.002). Logistic regression revealed that PaO.sub.2 /FiO.sub.2 on day 3 [odds ratio (OR), 1.010; 95% confidence interval (CI), 1.003-1.017], length of stay in a local hospital before admission to the central hospital (OR, 1.122; 95% CI, 1.042-1.210) due to stable condition, and SOFA score on Day 1 (OR, 0.842; 95% CI, 0.708-1.002) were independent factors in patient survival.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221114