Association of Polymorphism rs198977 in Human Kallikrein-2 Gene

Association of Polymorphism rs198977 in Human Kallikrein-2 Gene

To assess the association of polymorphism rs198977 in the human kallikrein-2 gene (KLK2) and risk of prostate cancer (PCa). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2013-06, Vol.8 (6), p.e65651
Hauptverfasser: Wang, Lishan, Zang, Weidong, Sang, Yunxia, Xie, Dongli, Wei, Li, Ji, Weidong, Pan, Yaosheng, Li, Zhiqiang, Shen, Jiawei, Shi, Yongyong
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Cancer genetics
Disease susceptibility
Genes
Genetic aspects
Genetic polymorphisms
Health aspects
Kallikrein
Prostate cancer
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To assess the association of polymorphism rs198977 in the human kallikrein-2 gene (KLK2) and risk of prostate cancer (PCa). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for rs198977 and PCa were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Six studies met the inclusion criteria in this meta-analysis, which included 5859 PCa cases and 4867 controls. Overall, rs198977 was associated with the PCa risk (TT+CT vs. CC, pooled OR = 1.163, 95% CI = 1.076-1.258, P-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065651