Voltammetric determination of papaverine and drotaverine

Voltammetric determination of papaverine and drotaverine

Isoquinoline derivatives (papaverine and drotaverine) are oxidized at a graphite electrode in a 0.1 M sulfuric acid solution to give voltammetric waves at 1.1 V for papaverine and at 1.05 and 1.28 V for drotaverine. Determination limits and linearity ranges of currents as functions of papaverine and...

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Veröffentlicht in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2007-08, Vol.62 (8), p.773-776
Hauptverfasser: Ziyatdinova, G. K., Samigullin, A. I., Budnikov, G. K.
Format: Artikel
Sprache:eng
Schlagworte:
Antispasmodics
Chemical properties
Electric currents
Electric properties
Methods
Observations
Papaverine
Voltammetry
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Zusammenfassung:Isoquinoline derivatives (papaverine and drotaverine) are oxidized at a graphite electrode in a 0.1 M sulfuric acid solution to give voltammetric waves at 1.1 V for papaverine and at 1.05 and 1.28 V for drotaverine. Determination limits and linearity ranges of currents as functions of papaverine and drotaverine concentrations are estimated. Microgram amounts of papaverine and drotaverine are determined in model solutions (RSD = 1-4%). A procedure for the direct determination of papaverine and drotaverine in pharmaceuticals is proposed.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934807080138