Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4
An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed tha...
Gespeichert in:
| Veröffentlicht in: | The Biological bulletin (Lancaster) 1998-06, Vol.194 (3), p.354-357 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 357 |
|---|---|
| container_issue | 3 |
| container_start_page | 354 |
| container_title | The Biological bulletin (Lancaster) |
| container_volume | 194 |
| creator | Nguyen, H. L. Gruber, D. McGraw, T. Sheetz, M. P. Bulinski, J. C. |
| description | An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed that MTs were more stabilized by full-length MAP4 compared to MT-binding domain of MAP4. The overexpression of MAP4 was linked to MT stabilization, cell growth parameters and inhibition of vesicle motility. |
| doi_str_mv | 10.2307/1543111 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_gale_incontextgauss_8GL_A20998356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A20998356</galeid><jstor_id>1543111</jstor_id><sourcerecordid>A20998356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c644t-86343f9defa93ef0b07cbe9d15774947d8c85f1bdf3178eddf5525a74c654a33</originalsourceid><addsrcrecordid>eNqN0l-LEzEQAPAgytmr4icQ9sG_cKtJk2w2j6V450HPE-7efFiyyaSmpJu6yYJ3n96UrWKh4pGHMJkfwyQZhF4Q_GFGsfhIOKOEkEdoQiSVZV1J8RhNMMZVSUnNn6LTGNc5xDPCTtCJrCpWVWSCvt0k1Trv7lVyoStUZ4rzodO7QPniKpjBj5lgiyun-5CGdvAQi_bu77icxxi0UwlM8TUfgusK9gw9scpHeL7fp-j2_NPt4nO5vL64XMyXpa4YS7lXyqiVBqySFCxusdAtSEO4EEwyYWpdc0taYykRNRhjOZ9xJZiuOFOUTtGbsey2Dz8GiKnZuKjBe9VBGGJT726NhfgvJBXnvMa7imcjXCkPjetsSL3SK-igVz50YF0-ns-wlDXlVeblEZ6XgY3Tx_y7A59Jgp9ppYYYm8ubLw-l9cXygJ4dozp4Dyto8osvrg_425HnP4yxB9tse7dR_V1DcLMbqWY_Ulm-3D_b0G7A_HH7Gcr592N-0N-dVquw7SF3tw5Dn2co_q7TbPMHTtHrh9jsXo1uHVPo_9naLwmi6Zo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16555803</pqid></control><display><type>article</type><title>Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Nguyen, H. L. ; Gruber, D. ; McGraw, T. ; Sheetz, M. P. ; Bulinski, J. C.</creator><creatorcontrib>Nguyen, H. L. ; Gruber, D. ; McGraw, T. ; Sheetz, M. P. ; Bulinski, J. C.</creatorcontrib><description>An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed that MTs were more stabilized by full-length MAP4 compared to MT-binding domain of MAP4. The overexpression of MAP4 was linked to MT stabilization, cell growth parameters and inhibition of vesicle motility.</description><identifier>ISSN: 0006-3185</identifier><identifier>EISSN: 1939-8697</identifier><identifier>DOI: 10.2307/1543111</identifier><identifier>PMID: 9664661</identifier><language>eng</language><publisher>United States: Marine Biological Laboratory</publisher><subject>Animals ; Binding Sites - genetics ; Brackish ; Cell Division - physiology ; Cell growth ; Cell interaction ; Cell interactions ; Cell lines ; Cell motility ; Freshwater ; Humans ; L Cells (Cell Line) ; Marine ; Membrane proteins ; Mice ; Microtubule associated proteins ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - physiology ; Microtubules ; Microtubules - physiology ; Microtubules and Viscoelasticity of Actin ; Mitosis ; Molecules ; Movement - physiology ; Organelles ; Organelles - physiology ; Polymerization ; Space life sciences ; Transfection</subject><ispartof>The Biological bulletin (Lancaster), 1998-06, Vol.194 (3), p.354-357</ispartof><rights>Copyright 1998 The Marine Biological Laboratory</rights><rights>Copyright © 1998 by Marine Biological Laboratory</rights><rights>COPYRIGHT 1998 University of Chicago Press</rights><rights>COPYRIGHT 1998 University of Chicago Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-86343f9defa93ef0b07cbe9d15774947d8c85f1bdf3178eddf5525a74c654a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1543111$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1543111$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9664661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, H. L.</creatorcontrib><creatorcontrib>Gruber, D.</creatorcontrib><creatorcontrib>McGraw, T.</creatorcontrib><creatorcontrib>Sheetz, M. P.</creatorcontrib><creatorcontrib>Bulinski, J. C.</creatorcontrib><title>Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4</title><title>The Biological bulletin (Lancaster)</title><addtitle>Biol Bull</addtitle><description>An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed that MTs were more stabilized by full-length MAP4 compared to MT-binding domain of MAP4. The overexpression of MAP4 was linked to MT stabilization, cell growth parameters and inhibition of vesicle motility.</description><subject>Animals</subject><subject>Binding Sites - genetics</subject><subject>Brackish</subject><subject>Cell Division - physiology</subject><subject>Cell growth</subject><subject>Cell interaction</subject><subject>Cell interactions</subject><subject>Cell lines</subject><subject>Cell motility</subject><subject>Freshwater</subject><subject>Humans</subject><subject>L Cells (Cell Line)</subject><subject>Marine</subject><subject>Membrane proteins</subject><subject>Mice</subject><subject>Microtubule associated proteins</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - physiology</subject><subject>Microtubules</subject><subject>Microtubules - physiology</subject><subject>Microtubules and Viscoelasticity of Actin</subject><subject>Mitosis</subject><subject>Molecules</subject><subject>Movement - physiology</subject><subject>Organelles</subject><subject>Organelles - physiology</subject><subject>Polymerization</subject><subject>Space life sciences</subject><subject>Transfection</subject><issn>0006-3185</issn><issn>1939-8697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0l-LEzEQAPAgytmr4icQ9sG_cKtJk2w2j6V450HPE-7efFiyyaSmpJu6yYJ3n96UrWKh4pGHMJkfwyQZhF4Q_GFGsfhIOKOEkEdoQiSVZV1J8RhNMMZVSUnNn6LTGNc5xDPCTtCJrCpWVWSCvt0k1Trv7lVyoStUZ4rzodO7QPniKpjBj5lgiyun-5CGdvAQi_bu77icxxi0UwlM8TUfgusK9gw9scpHeL7fp-j2_NPt4nO5vL64XMyXpa4YS7lXyqiVBqySFCxusdAtSEO4EEwyYWpdc0taYykRNRhjOZ9xJZiuOFOUTtGbsey2Dz8GiKnZuKjBe9VBGGJT726NhfgvJBXnvMa7imcjXCkPjetsSL3SK-igVz50YF0-ns-wlDXlVeblEZ6XgY3Tx_y7A59Jgp9ppYYYm8ubLw-l9cXygJ4dozp4Dyto8osvrg_425HnP4yxB9tse7dR_V1DcLMbqWY_Ulm-3D_b0G7A_HH7Gcr592N-0N-dVquw7SF3tw5Dn2co_q7TbPMHTtHrh9jsXo1uHVPo_9naLwmi6Zo</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Nguyen, H. L.</creator><creator>Gruber, D.</creator><creator>McGraw, T.</creator><creator>Sheetz, M. P.</creator><creator>Bulinski, J. C.</creator><general>Marine Biological Laboratory</general><general>University of Chicago Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>ISN</scope><scope>7TN</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4</title><author>Nguyen, H. L. ; Gruber, D. ; McGraw, T. ; Sheetz, M. P. ; Bulinski, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-86343f9defa93ef0b07cbe9d15774947d8c85f1bdf3178eddf5525a74c654a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Binding Sites - genetics</topic><topic>Brackish</topic><topic>Cell Division - physiology</topic><topic>Cell growth</topic><topic>Cell interaction</topic><topic>Cell interactions</topic><topic>Cell lines</topic><topic>Cell motility</topic><topic>Freshwater</topic><topic>Humans</topic><topic>L Cells (Cell Line)</topic><topic>Marine</topic><topic>Membrane proteins</topic><topic>Mice</topic><topic>Microtubule associated proteins</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubule-Associated Proteins - physiology</topic><topic>Microtubules</topic><topic>Microtubules - physiology</topic><topic>Microtubules and Viscoelasticity of Actin</topic><topic>Mitosis</topic><topic>Molecules</topic><topic>Movement - physiology</topic><topic>Organelles</topic><topic>Organelles - physiology</topic><topic>Polymerization</topic><topic>Space life sciences</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, H. L.</creatorcontrib><creatorcontrib>Gruber, D.</creatorcontrib><creatorcontrib>McGraw, T.</creatorcontrib><creatorcontrib>Sheetz, M. P.</creatorcontrib><creatorcontrib>Bulinski, J. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Canada</collection><collection>Oceanic Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>The Biological bulletin (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, H. L.</au><au>Gruber, D.</au><au>McGraw, T.</au><au>Sheetz, M. P.</au><au>Bulinski, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4</atitle><jtitle>The Biological bulletin (Lancaster)</jtitle><addtitle>Biol Bull</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>194</volume><issue>3</issue><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>0006-3185</issn><eissn>1939-8697</eissn><abstract>An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed that MTs were more stabilized by full-length MAP4 compared to MT-binding domain of MAP4. The overexpression of MAP4 was linked to MT stabilization, cell growth parameters and inhibition of vesicle motility.</abstract><cop>United States</cop><pub>Marine Biological Laboratory</pub><pmid>9664661</pmid><doi>10.2307/1543111</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3185 |
| ispartof | The Biological bulletin (Lancaster), 1998-06, Vol.194 (3), p.354-357 |
| issn | 0006-3185 1939-8697 |
| language | eng |
| recordid | cdi_gale_incontextgauss_8GL_A20998356 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Binding Sites - genetics Brackish Cell Division - physiology Cell growth Cell interaction Cell interactions Cell lines Cell motility Freshwater Humans L Cells (Cell Line) Marine Membrane proteins Mice Microtubule associated proteins Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Microtubules Microtubules - physiology Microtubules and Viscoelasticity of Actin Mitosis Molecules Movement - physiology Organelles Organelles - physiology Polymerization Space life sciences Transfection |
| title | Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T20%3A26%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stabilization%20and%20Functional%20Modulation%20of%20Microtubules%20by%20Microtubule-Associated%20Protein%204&rft.jtitle=The%20Biological%20bulletin%20(Lancaster)&rft.au=Nguyen,%20H.%20L.&rft.date=1998-06-01&rft.volume=194&rft.issue=3&rft.spage=354&rft.epage=357&rft.pages=354-357&rft.issn=0006-3185&rft.eissn=1939-8697&rft_id=info:doi/10.2307/1543111&rft_dat=%3Cgale_proqu%3EA20998356%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16555803&rft_id=info:pmid/9664661&rft_galeid=A20998356&rft_jstor_id=1543111&rfr_iscdi=true |