Stabilization and Functional Modulation of Microtubules by Microtubule-Associated Protein 4

An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed tha...

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Veröffentlicht in:	The Biological bulletin (Lancaster) 1998-06, Vol.194 (3), p.354-357
Hauptverfasser:	Nguyen, H. L., Gruber, D., McGraw, T., Sheetz, M. P., Bulinski, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Brackish Cell Division - physiology Cell growth Cell interaction Cell interactions Cell lines Cell motility Freshwater Humans L Cells (Cell Line) Marine Membrane proteins Mice Microtubule associated proteins Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Microtubules Microtubules - physiology Microtubules and Viscoelasticity of Actin Mitosis Molecules Movement - physiology Organelles Organelles - physiology Polymerization Space life sciences Transfection
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Beschreibung
Zusammenfassung:	An experiment was conducted to determine the in vivo functions of microtubule-associated protein 4 (MAP4) and its role in cell cycle and differentiation. The MAP4 was believed to be responsible in the regulation pf microtubule (MT) dynamics, organization and transport processes. Results revealed that MTs were more stabilized by full-length MAP4 compared to MT-binding domain of MAP4. The overexpression of MAP4 was linked to MT stabilization, cell growth parameters and inhibition of vesicle motility.
ISSN:	0006-3185 1939-8697
DOI:	10.2307/1543111