Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]

Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximideresistant mutants whose 80S ribosomes are resistant to cycloheximid...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1981-04, Vol.212 (4492), p.361-362
Hauptverfasser:	Nakashima, H, Perlman, J, Feldman, J.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Circadian rhythms Clocks Enzyme inhibitors Genes Liquids Neurospora Phase shift Protein biosynthesis Protein synthesis Ribosomes
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creator	Nakashima, H Perlman, J Feldman, J.F
description	Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximideresistant mutants whose 80S ribosomes are resistant to cycloheximide showed no phase shift after exposure to the drug.
doi_str_mv	10.1126/science.212.4492.361
format	Article
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The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximideresistant mutants whose 80S ribosomes are resistant to cycloheximide showed no phase shift after exposure to the drug.</description><subject>Circadian rhythms</subject><subject>Clocks</subject><subject>Enzyme inhibitors</subject><subject>Genes</subject><subject>Liquids</subject><subject>Neurospora</subject><subject>Phase shift</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Ribosomes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNpFkEFLAzEQhYMoWKt_QHrIXbYmm-xucixFq1DsQXsSCWk6aVPXTU1Ssf_elBaEgTm892YeH0IDSoaUlvV9NA46A8OSlkPOZTlkNT1DPUpkVciSsHPUI4TVhSBNdYmuYtwQkjXJekhPoIPkDIYftzwcwWmtE94Gn8B1OO67tIboIs4T4HvnAiyx9SHbABsXjF463WHTevOJvcUvsAs-bn3Q-P1x163cxzW6sLqNcHPafTR_fHgbPxXT2eR5PJoWhpVVKqysK12Xlle0Ac5YI4lYCGs50NpCwxoruGyY1ACLhag4pTUIkFoQZjQXDeuju-PdlW5Buc74LsFvMr5tYQUq_xrP1IgKISQn2c2PbpPrxgBWbYP70mGvKFEHqOoEVWWo6gBVZag5NjjGNjH58J-pc6OqyvLtUbbaK70KLqr5a27IOeHsD_Lcfpo</recordid><startdate>19810417</startdate><enddate>19810417</enddate><creator>Nakashima, H</creator><creator>Perlman, J</creator><creator>Feldman, J.F</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19810417</creationdate><title>Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]</title><author>Nakashima, H ; Perlman, J ; Feldman, J.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-f965a62f4517e4337908b8ff4e16fe737f849739aeebb854116e8e9a803ca4873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Circadian rhythms</topic><topic>Clocks</topic><topic>Enzyme inhibitors</topic><topic>Genes</topic><topic>Liquids</topic><topic>Neurospora</topic><topic>Phase shift</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Ribosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakashima, H</creatorcontrib><creatorcontrib>Perlman, J</creatorcontrib><creatorcontrib>Feldman, J.F</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakashima, H</au><au>Perlman, J</au><au>Feldman, J.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-04-17</date><risdate>1981</risdate><volume>212</volume><issue>4492</issue><spage>361</spage><epage>362</epage><pages>361-362</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. 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language	eng
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source	American Association for the Advancement of Science; Jstor Complete Legacy
subjects	Circadian rhythms Clocks Enzyme inhibitors Genes Liquids Neurospora Phase shift Protein biosynthesis Protein synthesis Ribosomes
title	Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]
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