Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]

Genetic evidence that protein synthesis is required for the circadian clock of Neurospora [Fungi]

Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximideresistant mutants whose 80S ribosomes are resistant to cycloheximid...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1981-04, Vol.212 (4492), p.361-362
Hauptverfasser: Nakashima, H, Perlman, J, Feldman, J.F
Format: Artikel
Sprache:eng
Schlagworte:
Circadian rhythms
Clocks
Enzyme inhibitors
Genes
Liquids
Neurospora
Phase shift
Protein biosynthesis
Protein synthesis
Ribosomes
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Zusammenfassung:Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximideresistant mutants whose 80S ribosomes are resistant to cycloheximide showed no phase shift after exposure to the drug.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.212.4492.361