The Type and the Position of HNF1A Mutation Modulate Age at Diagnosis of Diabetes in Patients with Maturity-Onset Diabetes of the Young (MODY)-3

The Type and the Position of HNF1A Mutation Modulate Age at Diagnosis of Diabetes in Patients with Maturity-Onset Diabetes of the Young (MODY)-3 Christine Bellanné-Chantelot 1 , Claire Carette 2 , Jean-Pierre Riveline 3 , René Valéro 4 , Jean-François Gautier 5 , Etienne Larger 6 9 , Yves Reznik 7 , Pierre-Henri Ducluzeau 8 , Agnès Sola 9 , Agnès Hartemann-Heurtier 10 , Pierre Lecomte 11 , Lucy Chaillous 12 , Marie Laloi-Michelin 13 , Jean-Marie Wilhem 14 , Pierre Cuny 15 , Françoise Duron 16 , Bruno Guerci 17 , Nathalie Jeandidier 18 , Helen Mosnier-Pudar 19 , Michel Assayag 20 , Danièle Dubois-Laforgue 2 , Gilberto Velho 21 and José Timsit 2 1 Department of Genetics, AP-HP Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie-Paris6, Paris, France 2 Department of Immunology and Diabetology, AP-HP Hôpital Cochin, Université René Descartes- Paris5, and Inserm, Research Unit 561, Paris, France 3 Department of Endocrinology, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France 4 Department of Nutrition-Metabolic Diseases-Endocrinology, AP-HM CHU de la Timone, Marseille, France 5 Department of Endocrinology, AP-HP Hôpital Saint-Louis, Université Denis Diderot-Paris7, Paris, France 6 Department of Diabetology, AP-HP Hôpital Bichat, Paris, France 7 Department of Endocrinology, CHU Caen, Caen, France 8 Department of Endocrinology, CHU Angers, Angers, France 9 Department of Diabetology, AP-HP Hôpital Hôtel Dieu, Paris, France 10 Department of Diabetology, AP-HP Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie-Paris6, Paris, France 11 Department of Endocrinology, CHU Bretonneau, Tours, France 12 Department of Endocrinology, CHU Nantes, Nantes, France 13 Department of Internal Medicine, AP-HP Hôpital Lariboisière, Paris, France 14 Department of Internal Medicine, Centre Hospitalier Saint-Morand, Altkirch, France 15 Department of Diabetology, Hôpital Beauregard, Thionville, France 16 Department of Endocrinology, AP-HP Hôpital Saint-Antoine, Paris, France 17 Department of Diabetology, CHU Nancy, Nancy, France 18 Department of Diabetology, CHU Strasbourg, Strasbourg, France 19 Department of Endocrinology, AP-HP Hôpital Cochin, Université Paris 5, Paris, France 20 Department of Internal Medicine, Centre Hospitalier Compiègne, Compiègne, France 21 Inserm, Research Unit 695, Paris, France Address correspondence and reprint requests to Christine Bellanné-Chantelot, Département de Génétique, Groupe Hospitalier Pitié-Salpétrière