Saccharin Metabolism and Tumorigenicity

Saccharin Metabolism and Tumorigenicity

Exposure of male Charles River CD1 rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo. No metabolites (< 0.06 microgram per kilogram...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1979-09, Vol.205 (4410), p.1019-1020
Hauptverfasser: Sweatman, T. W., Renwick, A. G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn - metabolism
Body weight
Carcinogenesis
Carcinogens
Diet
Dosage
Excretion
Male
Metabolism
Metabolites
Physiological aspects
Rats
Saccharin
Saccharin - adverse effects
Saccharin - metabolism
Saccharin - urine
Urine
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Beschreibung
Zusammenfassung:Exposure of male Charles River CD1 rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo. No metabolites (< 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.472722