Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study
Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Met...
Gespeichert in:
| Veröffentlicht in: | Neuroepidemiology 2021-06, Vol.55 (3), p.206-215 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 215 |
|---|---|
| container_issue | 3 |
| container_start_page | 206 |
| container_title | Neuroepidemiology |
| container_volume | 55 |
| creator | Smyth, Andrew Judge, Conor Wang, Xingu Pare, Guillaume Rangarajan, Sumathy Canavan, Michelle Chin, Siu Lim Al-Hussain, Fawaz Yusufali, Afzalhussein M. Elsayed, Ahmed Damasceno, Albertino Avezum, Alvaro Czlonkowska, Anna Rosengren, Annika Dans, Antonio L. Oguz, Aytekin Mondo, Charles Weimar, Christian Ryglewicz, Danuta Xavier, Denis Lanas, Fernando Malaga, German Hankey, Graeme J. Iversen, Helle K. Zhang, Hongye Yusoff, Khalid Pogosova, Nana Lopez-Jamarillo, Patricio Langhorne, Peter Diaz, Rafael Oveisgharan, Shahram Yusuf, Salim O’Donnell, Martin |
| description | Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR |
| doi_str_mv | 10.1159/000515239 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_healthsolutions_A707276492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A707276492</galeid><sourcerecordid>A707276492</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-a1d851a06a0f39f88096c0a7df5c8e7414899c93a24ae50e9bab6360a9d293a3</originalsourceid><addsrcrecordid>eNpt0cGL1DAUBvAgiju7evAuUhAWPXR9SZq28eSwjDq4uDDbe3jTvs7UaZtu0iL735ul4-CC5BD4-H2Bl8fYGw5XnCv9CQAUV0LqZ2zBEyFjEJA_ZwsQisdKKjhj597_Agg41y_ZmZRa8VSKBfuyoR7baN0N2LiO-jHCvoo2jT9Eto6W5TRSdDc6e6DPUbGnaP2zWG3uis3tj1XIp-rhFXtRY-vp9fG-YMXXVXH9Pb65_ba-Xt7EZZKIMUZe5YojpAi11HWeg05LwKyqVZlTlvAk17rUEkWCpID0FrepTAF1JUIqL1g8P-t_0zBtzeCaDt2DsdiY3TSYEO0m48lICB-RBf9h9oOz9xP50XSNL6ltsSc7eSOUEKngmeSBvp_pDlsyTV_b0WH5yM0yg0xkaaJFUFf_UeFU1DWl7aluQv6kcPlPYU_Yjntv22lsbO-fwo8zLJ313lF9Go6DedyvOe032HfHsaZtR9VJ_l1oAG9ncEC3I3cCx_4fpCWjeg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2522621731</pqid></control><display><type>article</type><title>Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study</title><source>Karger Journals</source><creator>Smyth, Andrew ; Judge, Conor ; Wang, Xingu ; Pare, Guillaume ; Rangarajan, Sumathy ; Canavan, Michelle ; Chin, Siu Lim ; Al-Hussain, Fawaz ; Yusufali, Afzalhussein M. ; Elsayed, Ahmed ; Damasceno, Albertino ; Avezum, Alvaro ; Czlonkowska, Anna ; Rosengren, Annika ; Dans, Antonio L. ; Oguz, Aytekin ; Mondo, Charles ; Weimar, Christian ; Ryglewicz, Danuta ; Xavier, Denis ; Lanas, Fernando ; Malaga, German ; Hankey, Graeme J. ; Iversen, Helle K. ; Zhang, Hongye ; Yusoff, Khalid ; Pogosova, Nana ; Lopez-Jamarillo, Patricio ; Langhorne, Peter ; Diaz, Rafael ; Oveisgharan, Shahram ; Yusuf, Salim ; O’Donnell, Martin</creator><creatorcontrib>Smyth, Andrew ; Judge, Conor ; Wang, Xingu ; Pare, Guillaume ; Rangarajan, Sumathy ; Canavan, Michelle ; Chin, Siu Lim ; Al-Hussain, Fawaz ; Yusufali, Afzalhussein M. ; Elsayed, Ahmed ; Damasceno, Albertino ; Avezum, Alvaro ; Czlonkowska, Anna ; Rosengren, Annika ; Dans, Antonio L. ; Oguz, Aytekin ; Mondo, Charles ; Weimar, Christian ; Ryglewicz, Danuta ; Xavier, Denis ; Lanas, Fernando ; Malaga, German ; Hankey, Graeme J. ; Iversen, Helle K. ; Zhang, Hongye ; Yusoff, Khalid ; Pogosova, Nana ; Lopez-Jamarillo, Patricio ; Langhorne, Peter ; Diaz, Rafael ; Oveisgharan, Shahram ; Yusuf, Salim ; O’Donnell, Martin ; INTERSTROKE investigators ; on behalf of the INTERSTROKE investigators</creatorcontrib><description>Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60 mL/min/1.73 m 2 . Multivariable conditional logistic regression was used to determine the association of renal function with stroke. Results: Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m 2 . The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0.001) and differed by region (p < 0.001). After adjustment, lower eGFR was associated with increased odds of stroke. Renal impairment was associated with increased odds of all stroke (OR 1.35; 95% CI: 1.24–1.47), with higher odds for intracerebral hemorrhage (OR 1.60; 95% CI: 1.35–1.89) than ischemic stroke (OR 1.29; 95% CI: 1.17–1.42) (p interaction 0.12). The largest magnitudes of association were seen in younger participants and those living in Africa, South Asia, or South America (p interaction < 0.001 for all stroke). Renal impairment was also associated with poorer clinical outcome (RRR 2.97; 95% CI: 2.50–3.54 for death within 1 month). Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.</description><identifier>ISSN: 0251-5350</identifier><identifier>EISSN: 1423-0208</identifier><identifier>DOI: 10.1159/000515239</identifier><identifier>PMID: 33951632</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Environmental & Occupational Health ; Kidney disease ; Kidney diseases ; Medical research ; Medicine, Experimental ; Neurosciences ; Neurosciences & Neurology ; Neurovetenskaper ; Original Paper ; Public ; Risk factors ; Stroke ; Stroke (Disease)</subject><ispartof>Neuroepidemiology, 2021-06, Vol.55 (3), p.206-215</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-a1d851a06a0f39f88096c0a7df5c8e7414899c93a24ae50e9bab6360a9d293a3</citedby><cites>FETCH-LOGICAL-c442t-a1d851a06a0f39f88096c0a7df5c8e7414899c93a24ae50e9bab6360a9d293a3</cites><orcidid>0000-0002-1956-1866 ; 0000-0001-9473-2920 ; 0000-0001-8542-9938 ; 0000-0002-3320-8292 ; 0000-0003-3378-2646 ; 0000-0002-2595-5167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2422,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33951632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/305237$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Smyth, Andrew</creatorcontrib><creatorcontrib>Judge, Conor</creatorcontrib><creatorcontrib>Wang, Xingu</creatorcontrib><creatorcontrib>Pare, Guillaume</creatorcontrib><creatorcontrib>Rangarajan, Sumathy</creatorcontrib><creatorcontrib>Canavan, Michelle</creatorcontrib><creatorcontrib>Chin, Siu Lim</creatorcontrib><creatorcontrib>Al-Hussain, Fawaz</creatorcontrib><creatorcontrib>Yusufali, Afzalhussein M.</creatorcontrib><creatorcontrib>Elsayed, Ahmed</creatorcontrib><creatorcontrib>Damasceno, Albertino</creatorcontrib><creatorcontrib>Avezum, Alvaro</creatorcontrib><creatorcontrib>Czlonkowska, Anna</creatorcontrib><creatorcontrib>Rosengren, Annika</creatorcontrib><creatorcontrib>Dans, Antonio L.</creatorcontrib><creatorcontrib>Oguz, Aytekin</creatorcontrib><creatorcontrib>Mondo, Charles</creatorcontrib><creatorcontrib>Weimar, Christian</creatorcontrib><creatorcontrib>Ryglewicz, Danuta</creatorcontrib><creatorcontrib>Xavier, Denis</creatorcontrib><creatorcontrib>Lanas, Fernando</creatorcontrib><creatorcontrib>Malaga, German</creatorcontrib><creatorcontrib>Hankey, Graeme J.</creatorcontrib><creatorcontrib>Iversen, Helle K.</creatorcontrib><creatorcontrib>Zhang, Hongye</creatorcontrib><creatorcontrib>Yusoff, Khalid</creatorcontrib><creatorcontrib>Pogosova, Nana</creatorcontrib><creatorcontrib>Lopez-Jamarillo, Patricio</creatorcontrib><creatorcontrib>Langhorne, Peter</creatorcontrib><creatorcontrib>Diaz, Rafael</creatorcontrib><creatorcontrib>Oveisgharan, Shahram</creatorcontrib><creatorcontrib>Yusuf, Salim</creatorcontrib><creatorcontrib>O’Donnell, Martin</creatorcontrib><creatorcontrib>INTERSTROKE investigators</creatorcontrib><creatorcontrib>on behalf of the INTERSTROKE investigators</creatorcontrib><title>Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study</title><title>Neuroepidemiology</title><addtitle>Neuroepidemiology</addtitle><description>Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60 mL/min/1.73 m 2 . Multivariable conditional logistic regression was used to determine the association of renal function with stroke. Results: Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m 2 . The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0.001) and differed by region (p < 0.001). After adjustment, lower eGFR was associated with increased odds of stroke. Renal impairment was associated with increased odds of all stroke (OR 1.35; 95% CI: 1.24–1.47), with higher odds for intracerebral hemorrhage (OR 1.60; 95% CI: 1.35–1.89) than ischemic stroke (OR 1.29; 95% CI: 1.17–1.42) (p interaction 0.12). The largest magnitudes of association were seen in younger participants and those living in Africa, South Asia, or South America (p interaction < 0.001 for all stroke). Renal impairment was also associated with poorer clinical outcome (RRR 2.97; 95% CI: 2.50–3.54 for death within 1 month). Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.</description><subject>Environmental & Occupational Health</subject><subject>Kidney disease</subject><subject>Kidney diseases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Neurovetenskaper</subject><subject>Original Paper</subject><subject>Public</subject><subject>Risk factors</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><issn>0251-5350</issn><issn>1423-0208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpt0cGL1DAUBvAgiju7evAuUhAWPXR9SZq28eSwjDq4uDDbe3jTvs7UaZtu0iL735ul4-CC5BD4-H2Bl8fYGw5XnCv9CQAUV0LqZ2zBEyFjEJA_ZwsQisdKKjhj597_Agg41y_ZmZRa8VSKBfuyoR7baN0N2LiO-jHCvoo2jT9Eto6W5TRSdDc6e6DPUbGnaP2zWG3uis3tj1XIp-rhFXtRY-vp9fG-YMXXVXH9Pb65_ba-Xt7EZZKIMUZe5YojpAi11HWeg05LwKyqVZlTlvAk17rUEkWCpID0FrepTAF1JUIqL1g8P-t_0zBtzeCaDt2DsdiY3TSYEO0m48lICB-RBf9h9oOz9xP50XSNL6ltsSc7eSOUEKngmeSBvp_pDlsyTV_b0WH5yM0yg0xkaaJFUFf_UeFU1DWl7aluQv6kcPlPYU_Yjntv22lsbO-fwo8zLJ313lF9Go6DedyvOe032HfHsaZtR9VJ_l1oAG9ncEC3I3cCx_4fpCWjeg</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Smyth, Andrew</creator><creator>Judge, Conor</creator><creator>Wang, Xingu</creator><creator>Pare, Guillaume</creator><creator>Rangarajan, Sumathy</creator><creator>Canavan, Michelle</creator><creator>Chin, Siu Lim</creator><creator>Al-Hussain, Fawaz</creator><creator>Yusufali, Afzalhussein M.</creator><creator>Elsayed, Ahmed</creator><creator>Damasceno, Albertino</creator><creator>Avezum, Alvaro</creator><creator>Czlonkowska, Anna</creator><creator>Rosengren, Annika</creator><creator>Dans, Antonio L.</creator><creator>Oguz, Aytekin</creator><creator>Mondo, Charles</creator><creator>Weimar, Christian</creator><creator>Ryglewicz, Danuta</creator><creator>Xavier, Denis</creator><creator>Lanas, Fernando</creator><creator>Malaga, German</creator><creator>Hankey, Graeme J.</creator><creator>Iversen, Helle K.</creator><creator>Zhang, Hongye</creator><creator>Yusoff, Khalid</creator><creator>Pogosova, Nana</creator><creator>Lopez-Jamarillo, Patricio</creator><creator>Langhorne, Peter</creator><creator>Diaz, Rafael</creator><creator>Oveisgharan, Shahram</creator><creator>Yusuf, Salim</creator><creator>O’Donnell, Martin</creator><general>S. Karger AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><orcidid>https://orcid.org/0000-0002-1956-1866</orcidid><orcidid>https://orcid.org/0000-0001-9473-2920</orcidid><orcidid>https://orcid.org/0000-0001-8542-9938</orcidid><orcidid>https://orcid.org/0000-0002-3320-8292</orcidid><orcidid>https://orcid.org/0000-0003-3378-2646</orcidid><orcidid>https://orcid.org/0000-0002-2595-5167</orcidid></search><sort><creationdate>20210601</creationdate><title>Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study</title><author>Smyth, Andrew ; Judge, Conor ; Wang, Xingu ; Pare, Guillaume ; Rangarajan, Sumathy ; Canavan, Michelle ; Chin, Siu Lim ; Al-Hussain, Fawaz ; Yusufali, Afzalhussein M. ; Elsayed, Ahmed ; Damasceno, Albertino ; Avezum, Alvaro ; Czlonkowska, Anna ; Rosengren, Annika ; Dans, Antonio L. ; Oguz, Aytekin ; Mondo, Charles ; Weimar, Christian ; Ryglewicz, Danuta ; Xavier, Denis ; Lanas, Fernando ; Malaga, German ; Hankey, Graeme J. ; Iversen, Helle K. ; Zhang, Hongye ; Yusoff, Khalid ; Pogosova, Nana ; Lopez-Jamarillo, Patricio ; Langhorne, Peter ; Diaz, Rafael ; Oveisgharan, Shahram ; Yusuf, Salim ; O’Donnell, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a1d851a06a0f39f88096c0a7df5c8e7414899c93a24ae50e9bab6360a9d293a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Environmental & Occupational Health</topic><topic>Kidney disease</topic><topic>Kidney diseases</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Neurovetenskaper</topic><topic>Original Paper</topic><topic>Public</topic><topic>Risk factors</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smyth, Andrew</creatorcontrib><creatorcontrib>Judge, Conor</creatorcontrib><creatorcontrib>Wang, Xingu</creatorcontrib><creatorcontrib>Pare, Guillaume</creatorcontrib><creatorcontrib>Rangarajan, Sumathy</creatorcontrib><creatorcontrib>Canavan, Michelle</creatorcontrib><creatorcontrib>Chin, Siu Lim</creatorcontrib><creatorcontrib>Al-Hussain, Fawaz</creatorcontrib><creatorcontrib>Yusufali, Afzalhussein M.</creatorcontrib><creatorcontrib>Elsayed, Ahmed</creatorcontrib><creatorcontrib>Damasceno, Albertino</creatorcontrib><creatorcontrib>Avezum, Alvaro</creatorcontrib><creatorcontrib>Czlonkowska, Anna</creatorcontrib><creatorcontrib>Rosengren, Annika</creatorcontrib><creatorcontrib>Dans, Antonio L.</creatorcontrib><creatorcontrib>Oguz, Aytekin</creatorcontrib><creatorcontrib>Mondo, Charles</creatorcontrib><creatorcontrib>Weimar, Christian</creatorcontrib><creatorcontrib>Ryglewicz, Danuta</creatorcontrib><creatorcontrib>Xavier, Denis</creatorcontrib><creatorcontrib>Lanas, Fernando</creatorcontrib><creatorcontrib>Malaga, German</creatorcontrib><creatorcontrib>Hankey, Graeme J.</creatorcontrib><creatorcontrib>Iversen, Helle K.</creatorcontrib><creatorcontrib>Zhang, Hongye</creatorcontrib><creatorcontrib>Yusoff, Khalid</creatorcontrib><creatorcontrib>Pogosova, Nana</creatorcontrib><creatorcontrib>Lopez-Jamarillo, Patricio</creatorcontrib><creatorcontrib>Langhorne, Peter</creatorcontrib><creatorcontrib>Diaz, Rafael</creatorcontrib><creatorcontrib>Oveisgharan, Shahram</creatorcontrib><creatorcontrib>Yusuf, Salim</creatorcontrib><creatorcontrib>O’Donnell, Martin</creatorcontrib><creatorcontrib>INTERSTROKE investigators</creatorcontrib><creatorcontrib>on behalf of the INTERSTROKE investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Neuroepidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smyth, Andrew</au><au>Judge, Conor</au><au>Wang, Xingu</au><au>Pare, Guillaume</au><au>Rangarajan, Sumathy</au><au>Canavan, Michelle</au><au>Chin, Siu Lim</au><au>Al-Hussain, Fawaz</au><au>Yusufali, Afzalhussein M.</au><au>Elsayed, Ahmed</au><au>Damasceno, Albertino</au><au>Avezum, Alvaro</au><au>Czlonkowska, Anna</au><au>Rosengren, Annika</au><au>Dans, Antonio L.</au><au>Oguz, Aytekin</au><au>Mondo, Charles</au><au>Weimar, Christian</au><au>Ryglewicz, Danuta</au><au>Xavier, Denis</au><au>Lanas, Fernando</au><au>Malaga, German</au><au>Hankey, Graeme J.</au><au>Iversen, Helle K.</au><au>Zhang, Hongye</au><au>Yusoff, Khalid</au><au>Pogosova, Nana</au><au>Lopez-Jamarillo, Patricio</au><au>Langhorne, Peter</au><au>Diaz, Rafael</au><au>Oveisgharan, Shahram</au><au>Yusuf, Salim</au><au>O’Donnell, Martin</au><aucorp>INTERSTROKE investigators</aucorp><aucorp>on behalf of the INTERSTROKE investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study</atitle><jtitle>Neuroepidemiology</jtitle><addtitle>Neuroepidemiology</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>55</volume><issue>3</issue><spage>206</spage><epage>215</epage><pages>206-215</pages><issn>0251-5350</issn><eissn>1423-0208</eissn><abstract>Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60 mL/min/1.73 m 2 . Multivariable conditional logistic regression was used to determine the association of renal function with stroke. Results: Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m 2 . The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0.001) and differed by region (p < 0.001). After adjustment, lower eGFR was associated with increased odds of stroke. Renal impairment was associated with increased odds of all stroke (OR 1.35; 95% CI: 1.24–1.47), with higher odds for intracerebral hemorrhage (OR 1.60; 95% CI: 1.35–1.89) than ischemic stroke (OR 1.29; 95% CI: 1.17–1.42) (p interaction 0.12). The largest magnitudes of association were seen in younger participants and those living in Africa, South Asia, or South America (p interaction < 0.001 for all stroke). Renal impairment was also associated with poorer clinical outcome (RRR 2.97; 95% CI: 2.50–3.54 for death within 1 month). Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>33951632</pmid><doi>10.1159/000515239</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1956-1866</orcidid><orcidid>https://orcid.org/0000-0001-9473-2920</orcidid><orcidid>https://orcid.org/0000-0001-8542-9938</orcidid><orcidid>https://orcid.org/0000-0002-3320-8292</orcidid><orcidid>https://orcid.org/0000-0003-3378-2646</orcidid><orcidid>https://orcid.org/0000-0002-2595-5167</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0251-5350 |
| ispartof | Neuroepidemiology, 2021-06, Vol.55 (3), p.206-215 |
| issn | 0251-5350 1423-0208 |
| language | eng |
| recordid | cdi_gale_healthsolutions_A707276492 |
| source | Karger Journals |
| subjects | Environmental & Occupational Health Kidney disease Kidney diseases Medical research Medicine, Experimental Neurosciences Neurosciences & Neurology Neurovetenskaper Original Paper Public Risk factors Stroke Stroke (Disease) |
| title | Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A03%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20Impairment%20and%20Risk%20of%20Acute%20Stroke:%20The%20INTERSTROKE%20Study&rft.jtitle=Neuroepidemiology&rft.au=Smyth,%20Andrew&rft.aucorp=INTERSTROKE%20investigators&rft.date=2021-06-01&rft.volume=55&rft.issue=3&rft.spage=206&rft.epage=215&rft.pages=206-215&rft.issn=0251-5350&rft.eissn=1423-0208&rft_id=info:doi/10.1159/000515239&rft_dat=%3Cgale_cross%3EA707276492%3C/gale_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2522621731&rft_id=info:pmid/33951632&rft_galeid=A707276492&rfr_iscdi=true |