Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study

Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study

Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Met...

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Veröffentlicht in:Neuroepidemiology 2021-06, Vol.55 (3), p.206-215
Hauptverfasser: Smyth, Andrew, Judge, Conor, Wang, Xingu, Pare, Guillaume, Rangarajan, Sumathy, Canavan, Michelle, Chin, Siu Lim, Al-Hussain, Fawaz, Yusufali, Afzalhussein M., Elsayed, Ahmed, Damasceno, Albertino, Avezum, Alvaro, Czlonkowska, Anna, Rosengren, Annika, Dans, Antonio L., Oguz, Aytekin, Mondo, Charles, Weimar, Christian, Ryglewicz, Danuta, Xavier, Denis, Lanas, Fernando, Malaga, German, Hankey, Graeme J., Iversen, Helle K., Zhang, Hongye, Yusoff, Khalid, Pogosova, Nana, Lopez-Jamarillo, Patricio, Langhorne, Peter, Diaz, Rafael, Oveisgharan, Shahram, Yusuf, Salim, O’Donnell, Martin
Format: Artikel
Sprache:eng
Schlagworte:
Environmental & Occupational Health
Kidney disease
Kidney diseases
Medical research
Medicine, Experimental
Neurosciences
Neurosciences & Neurology
Neurovetenskaper
Original Paper
Public
Risk factors
Stroke
Stroke (Disease)
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Zusammenfassung:Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR
ISSN:0251-5350
1423-0208
DOI:10.1159/000515239