Evaluation of the Effect of Intravitreal Dexamethasone

Objectives: This study aimed to retrospectively evaluate the intraocular pressure (IOP) change in vitrectomized and non-vitrectomized patients receiving 0.7 mg intravitreal dexamethasone implant to treat macular edema due to different indications. Materials and Methods: The patients' diagnoses, IOP values before receiving the intravitreal dexamethasone implant and in follow-up examinations at 1-3 days, 1 month, 2 months, 3 months, 6 months, 9 months, and 12 months after implantation, pachymetry values, medications used, and history of vitrectomy surgery were recorded. Results: A total of 134 eyes of 112 patients between 46 and 85 years of age who received intravitreal dexamethasone implants were evaluated. Seventeen eyes (12.7%) were vitrectomized and 117 (87.3%) were not vitrectomized. In non-vitrectomized eyes, the mean IOP was 14.01[+ or -]2.36 mmHg before and 14.8[+ or -]2.96 at 1-3 days, 16.71[+ or -]3.97 at 1 month, 17.88[+ or -]5.27 at 2 months, 15.54[+ or -]3.35 at 3 months, 15.1[+ or -]3.24 at 6 months, and 14.61[+ or -]3.71 mmHg at 12 months after receiving the first dose. In this group, the increases in mean IOP at 1-3 days, 1 month, 2 months, and 3 months were significant compared to the mean IOP before the first dose (p