Microbial DNA signature in plasma enables cancer diagnosis

Microbial DNA signature in plasma enables cancer diagnosis

Bacteria within tumours affect progression and response to therapy; in addition, bacterial DNA can be detected in cell-free plasma. Herein, we discuss evidence showing that intratumoural bacteria are characteristic for each tumour type, and that detection of cell-free bacterial DNA in blood could pr...

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Veröffentlicht in:Nature reviews. Clinical oncology 2020-08, Vol.17 (8), p.453-454
Hauptverfasser: Dzutsev, Amiran, Trinchieri, Giorgio
Format: Artikel
Sprache:eng
Schlagworte:
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Bacteria
Blood
Cancer
Deoxyribonucleic acid
Diagnosis
Diseases
DNA
Genetic aspects
Humans
Life Sciences & Biomedicine
Medical diagnosis
Medical examination
Medicine
Medicine & Public Health
Microbiota
Neoplasms - diagnosis
Neoplasms - genetics
News & Views
news-and-views
Oncology
Oncology, Experimental
Relapse
Science & Technology
Tumors
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Beschreibung
Zusammenfassung:Bacteria within tumours affect progression and response to therapy; in addition, bacterial DNA can be detected in cell-free plasma. Herein, we discuss evidence showing that intratumoural bacteria are characteristic for each tumour type, and that detection of cell-free bacterial DNA in blood could provide an accurate and non-invasive test for cancer diagnosis.
ISSN:1759-4774
1759-4782
DOI:10.1038/s41571-020-0391-1