New insights into the obesity paradox in renal cell carcinoma

Paradoxically, elevated BMI is a recognized positive prognostic factor in renal cell carcinoma (RCC). A recent investigation of the transcriptomic signatures of RCC tumours and peritumoural tissues suggests potential biological mechanisms underlying this effect. However, the clinical utility of BMI...

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Veröffentlicht in:	Nature reviews. Nephrology 2020-05, Vol.16 (5), p.253-254
Hauptverfasser:	Gan, Chun Loo, Heng, Daniel Y. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/580 692/163/2743/393 692/4022/1585/1588/1351 692/4028/67/2328 Angiogenesis Body Mass Index Cancer therapies Carcinoma, Renal Cell Cohort Studies Complications and side effects Consortia Genetic aspects Health aspects Humans Hypoxia Immunotherapy Kidney cancer Kidney Neoplasms Kinases Medicine Medicine & Public Health Melanoma Metastasis Nephrology News & Views news-and-views Obesity Patient outcomes Patients Researchers Risk factors Transcriptome Tumors Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Paradoxically, elevated BMI is a recognized positive prognostic factor in renal cell carcinoma (RCC). A recent investigation of the transcriptomic signatures of RCC tumours and peritumoural tissues suggests potential biological mechanisms underlying this effect. However, the clinical utility of BMI in the context of RCC remains uncertain.
ISSN:	1759-5061 1759-507X
DOI:	10.1038/s41581-020-0264-y